Download |TOP| General Topology Willard Pdf Zip
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In the top table, we rank a model in the same order as in Figure 2, with the following modifications: (i) we only considered the best scoring PPI networks for each tissue, (ii) we use only the topological alignment p-values as a basis for comparison, (iii) we only consider alignments for which the original tissue network has a p-value above the upper bound, (iv) we include only p-values for which the alignment is significantly better than random in the original tissue network, (v) we consider a p-value of 0.05 to be significantly better than random, (vi) we include both p-values for the homological alignment and the topological alignment, (vii) we only consider alignments for which the homological p-value is significantly better than random, (viii) we include alignments for which both the topological and the homological p-values are significantly better than random, and (ix) we consider alignments with a score of ≥ 0.5 to be significantly better than random. The results for the other tissues of the same rank are available as Additional file 6.
Figure 2b reports the homological p-values, which are similar to the topological p-values but are generally lower, as are the alignment p-values. The p-values for the pancreas and the brain networks are generally higher than those for the other networks. The p-values for the heart and the lung networks are generally higher than those for the other networks. The p-values for the kidney and the spleen networks are generally lower than those for the other networks.
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